Each API key has its own separate nonce, and the nonce value is persistent, which means the most recently used nonce will remain unchanged even if an API key is not used for some time.
Note that it is not possible to reset the nonce for a specific API key. In the event that a nonce value becomes invalid (such as accidentally using a UNIX timestamp far into the future), the solution would be to delete the affected API key and generate a new API key, which would automatically have a new starting nonce value of 0 (zero).